The Isaac Melvin House is a historic house at 19 Centre Street in Cambridge, Massachusetts. This 2+1⁄2-story Greek Revival-Italianate house was built in 1842 by Oliver Wood and Isaac Melvin as the latter's home. Melvin is also notable for designing the North Avenue Congregational Church. Despite an Italianate T-shaped massing, the building's front facade is strongly Greek Revival, with 4 two-story pilasters supporting an entablature and topped by the fully pedimented gable end of the roof. The tympanum of the pediment has an Italianate round-arch window in it.